Surfactant Proteins A and D Enhance Pulmonary Clearance ofPseudomonas aeruginosa
نویسندگان
چکیده
منابع مشابه
Pulmonary surfactant proteins A and D enhance neutrophil uptake of bacteria.
The collectins are a class of collagenous lectin proteins present in serum and pulmonary secretions [pulmonary surfactant protein (SP) A and SP-D] that are believed to participate in innate immune responses to various pathogens. With the use of flow cytometric and fluorescent-microscopic assays, SP-A and SP-D were shown to increase calcium-dependent neutrophil uptake of Escherichia coli, Strept...
متن کاملNon-Pulmonary Immune Functions of Surfactant Proteins A and D.
Surfactant proteins A (SP-A) and D (SP-D) are established as essential components of our innate immune system for protecting the lung from pathogens and allergens. They essentially exert their protective functions by regulating pulmonary homeostasis. Both proteins are however widely expressed throughout the body, including the female reproductive tract, urinary tract, gastrointestinal tract, th...
متن کاملSurfactant proteins A and D.
30. Erdei, A. and Reid, K. B. M. (1989) Behring Inst. Mitt. 84,216-219 31. Malhotra, R., Thiel, S., Reid, K. B. M. and Sim, R. B. (1990) J. Exp. Med. 172,955-959 32. Malhotra, R.. Haurum, J.? Thiel, S. and Sim, R. B. (1 992) Eur. J. Immunol. 22,14371445 33. Guan, E., Burgess, W. H., Robinson, S. I+ Goodman, E. B., McTigue, K. H. and Tenner, A. J. (1991) J. Biol. Chem. 266,20345-20355 34. Priis-...
متن کاملSurfactant proteins A and D enhance the phagocytosis of Chlamydia into THP-1 cells.
Chlamydiae are intracellular bacterial pathogens that infect mucosal surfaces, i.e., the epithelium of the lung, genital tract, and conjunctiva of the eye, as well as alveolar macrophages. In the present study, we show that pulmonary surfactant protein A (SP-A) and surfactant protein D (SP-D), lung collectins involved in innate host defense, enhance the phagocytosis of Chlamydia pneumoniae and ...
متن کاملSurfactant protein-d enhances phagocytosis and pulmonary clearance of respiratory syncytial virus.
Surfactant protein (SP)-D gene targeted (SP-D-/-) and wild-type mice were infected with respiratory syncytial virus (RSV) by intratracheal instillation. Decreased clearance of RSV was observed in SP-D-/- mice. Deficiency of SP-D was associated with increased inflammation and inflammatory cell recruitment in the lung after infection. In vitro, SP-D bound RSV-infected Vero cells. Binding was inhi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2006
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2005-0461oc